Chikwata chaWu Guangming: Mazuva makumi matatu neshanu ekutanga ACE2 humanized mbeva modhi

Mukurwisa denda mukutanga kwa2020, mumazuva makumi matatu neshanu chete, modhi yeACE2 mbeva yakamiswa, uye muongorori Guangming Wu nevamwe vake kubva kuCentre for Cell Fate uye Lineage Research (CCLA) kuBio-Island Laboratories vakabudirira kuita sarudzo. budiriro huru uchishandisa stem cell tekinoroji kugadzira "kurwa neNew Coronary Pneumonia".Chishamiso chekukurumidza mukurwiswa kwechimbichimbi.

Muedzo wakaerekana

Muna Nyamavhuvhu 2019, Wu Guangming, muongorori wenguva refu mundima yekusimudzira embryonic, akadzokera kuGuangzhou achibva kuGermany kuzobatana neboka rekutanga re "Guangdong Province kuvaka boka renyika rekuchengetedza laboratory" yeBio-Island Laboratory, inova Guangzhou Guangdong Laboratory yeRegenerative Medicine uye Hutano.

Zvaasina kutarisira ndezvekuti hazvizotora nguva refu asati atarisana nemuedzo usingatarisirwi wekorona itsva pneumonia kubuda.

"Nyaya yekutsvagisa yandiri kuita haina chekuita nezvirwere zvinotapukira, asi takatarisana nedenda riri kuuya, mushure mekuziva kuti Guangdong Provincial department reScience neTekinoroji rakagadzira chirongwa chakakosha chekutsvaga kwechimbichimbi pamusoro pekorona itsva. pneumonia, ndakanetseka kuti chii chandaigona kuita kurwisa denda iri nyika yese yaishanda pamwe chete. "

Kuburikidza nekunzwisisa, Wu Guangming akawana kuti mhando dzemhuka dzemunhu dzinodiwa nekukasira kuongororwa uye kurapwa kweiyo coronavirus nyowani pamwe nekutonga kwayo kwenguva refu.Iyo inonzi inonzi humanized mhuka modhi ndeyekugadzira mhuka (tsoko, mbeva, nezvimwewo) dzine humwe hunhu hwematishu evanhu, nhengo, uye masero kuburikidza nekugadzirisa majini uye dzimwe nzira dzekugadzira mhando dzechirwere, kudzidza nzira dzepathogenic dzezvirwere zvevanhu uye kuwana. mhinduro dzakanakisisa dzokurapa.

Kurwisa kwacho kwakapedzwa mumazuva makumi matatu nemashanu

Wu Guangming akaudza mutori wenhau kuti kwaingova nemhando dze in vitro cell panguva iyoyo uye vanhu vazhinji vainetsekana.Akave ane makore mazhinji eruzivo mukutsvagisa mhuka dze transgenic uye aivewo akanaka pa tetraploid compensation tekinoroji.Imwe yemazano ake ekutsvagisa kare ikako yaive yekusanganisa embryonic stem cell tekinoroji uye embryonic tetraploid muripo wetekinoroji pamwechete kuti vamise mhando dzembeva dzevanhu, uye zvaikurudzira kuti Center for Cell Fate uye Genealogy Research kuBio Island Laboratories yakazove neinotungamira stem cell tekinoroji. , uye zvaiita sokuti zvinhu zvose zvokunze zvakanga zvaibva.

Kufunga chinhu chimwe, kuita ndechimwe.

Zvakaoma sei kugadzira modhi inogona kushandiswa?Pasi pemaitiro akajairwa, zvinotora ingangoita mwedzi mitanhatu uye kupinda nemuyedzo isingaverengeke uye kukanganisa maitiro.Asi mukutarisana nedenda rekukurumidzira, munhu anofanirwa kumhanyisana nenguva uye akanamatira pamepu.

Chikwata ichi chakavambwa zvechimbichimbi nekuti vanhu vazhinji vaive vatoenda kudzimba kugore idzva rekuChina.Pakupedzisira, vanhu vasere vakasara muGuangzhou vakawanikwa vari pasi peCentre for Cell Fate uye Genealogy Research sangano kuti vagadzire timu yenguva pfupi yekurwisa mbeva.

Kubva padhizaini yekuyedza protocol muna Ndira 31 kusvika pakuzvarwa kwechizvarwa chekutanga chembeva dzakaitwa vanhu munaKurume 6, timu yakazadzisa ichi chishamiso chekutsvagisa kwesainzi mumazuva makumi matatu nemashanu chete.Tekinoroji yakajairwa inoda kusanganisa mbeva stem maseru uye embryos kuti uwane chimeric mbeva, uye chete kana stem masero asiyana kuita majemusi maseru obva asangana nemamwe mbeva kupfuudza majini akagadziridzwa kuchizvarwa chinotevera chembeva anogona kunzi akabudirira.Mbeva dzakaitwa nevanhu kubva kuCCLA dzakazvarwa kuti dziwane chinangwa chekugogodza-mumbeva kamwechete, kuwana nguva yakakosha uye kuchengetedza vashandi uye zviwanikwa zvekurwisa denda.

nhau

Wu Guangming kubasa Mufananidzo/wakapihwa nemubvunzurudzo

Vese vachishanda overtime

Wu Guangming akabvuma kuti pakutanga, hapana moyo wemunhu aive nepasi, uye tetraploid tekinoroji pachayo yaive yakaoma zvakanyanya, nekubudirira kuri pasi pe2%.

Panguva iyoyo, vanhu vose vakanga vakazvipira zvizere pakunzvera, pasinei zvapo nemasikati nousiku, pasina mazuva okushanda uye kupera kwevhiki.Zuva nezuva na3:00 kana 4:00 mangwanani, nhengo dzeboka dzaikurukura mafambiro ezuva;vakakurukura kusvika kwayedza ndokubva vadzokera kune rimwe zuva retsvakurudzo.

Semutungamiri wehunyanzvi wechikwata chekutsvagisa, Wu Guangming anofanirwa kuenzanisa zvinhu zviviri zvebasa - kugadzirisa majini uye embryo tsika - uye anofanirwa kutevedzera nhanho yega yekuyedza uye kugadzirisa matambudziko nenguva, izvo zvinoshungurudza kupfuura munhu anogona. imagine.

Panguva iyoyo, nekuda kwezororo reMutambo weChirimo uye denda, zvese zvaidiwa zvakange zvapera, uye taifanira kutsvaga vanhu kwese kwese kuti vavakwerete.Basa remazuva ese raive rekuyedza, kuyedza, kutumira masampula uye kutsvaga reagents.

Kuti vakurumidze nguva, timu yekutsvagisa yakatyora iyo yakajairwa mamiriro ekuyedza, ukuwo kugadzirira kwekutanga kwega rega rinotevera rekuyedza nhanho.Asi izvi zvinoreva zvakare kuti kana chimwe chinhu chikatadza mumatanho apfuura, matanho anotevera anogadzirirwa pasina.

Zvisinei, zviedzo zvebhayoloji pachazvo inzira inoda kugara ichiyedzwa nekukanganisa.

Wu Guangming achiri kurangarira kuti kamwe, iyo in vitro vector yakashandiswa kuisa mukati memasero eDNA kutevedzana, asi haina kushanda, saka aifanira kugadzirisa iyo reagent concentration uye mamwe ma parameter kakawanda uyezve uye achizviita zvakare uye zvakare kusvika iyo. akashanda.

Basa racho rainetsa zvekuti munhu wese ainge awanda, vamwe vaive nemapundu mukanwa, vamwe vainge vakaneta zvekuti vaingotsikitsira pasi kuti vataure nekuti vaisakwanisa kusimuka.

Kuti abudirire, Wu Guangming, zvisinei, akatotaura kuti aive nerombo rakanaka kusangana neboka revatambi vechikwata vakanaka, uye zvaive zvakanaka kupedzisa kuvakwa kwemodhi yembeva munguva pfupi yakadaro.

Ndichiri kuda kuwedzera kuvandudza

Musi waKurume 6, 17 chizvarwa chekutanga mbeva dzevanhu dzakabudirira kuberekwa.Nekudaro, izvi zvinongogona kutsanangurwa sedanho rekutanga mukupedzwa kwebasa, iro rakakurumidza kuteverwa neyakaomarara nzira yekusimbisa uye kutumira mbeva dzakagadzirwa nevanhu kuP3 lab kuti ibudirire kuongororwa hutachiona.

Nekudaro, Wu Guangming akafungawo nezveimwe gadziriso kune mbeva modhi.

Akaudza vatori venhau kuti 80% yevarwere vane COVID-19 vane asymptomatic kana kuti vanorwara zvinyoro, zvichireva kuti vanogona kuvimba nekuzvidzivirira kwavo kuti vapore, nepo vamwe makumi maviri muzana evarwere vachirwara nechirwere chakakomba, kunyanya kune vakweguru kana avo vane zvirwere. .Naizvozvo, kuitira kunyatsoshandisa uye nemazvo kushandisa mbeva mhando dzechirwere, mushonga, uye vaccine tsvagiridzo, timu iri kunanga vanhu mbeva pamwe nekuchembera nguva isati yakwana, chirwere cheshuga, hypertension, uye mamwe maitiro ezvirwere kuti atange chirwere chakakomba mbeva modhi.

Achifunga nezvebasa rakasimba, Wu Guangming akati aidada nechikwata chakadaro, uko munhu wese ainzwisisa kukosha kwezvavaiita, aine ruzivo rwepamusoro, uye akashanda nesimba kuti awane mhedzisiro yakadaro.

Related news links:"Guangdong Hondo Denda Kukudza Magamba" Chikwata chaWu Guangming: mazuva makumi matatu nemashanu ekutanga ACE2 humanized mbeva modhi (baidu.com)


Nguva yekutumira: Aug-02-2023