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Pharmacological efficacy analysis

pharmacological-efficacy-analysis-chigadzirwa

Pharmacological efficacy analysis inoreva kuongororwa uye kuongororwa kwekushanda kwemishonga mukuzadzisa chinangwa chavo chekurapa.Idanho rakakosha mukugadzirwa kwezvinodhaka uye rinojekesa mabhenefiti angaita uye zvipimo zvemushonga wemishonga.

Kuburikidza nekuongorora kwezvekuita kwemishonga, vaongorori vanovavarira kuona kuti mushonga unobatana sei neinotarirwa receptor kana biological system, zvichitungamira kune inodiwa physiological mhinduro.

MingCeler inogona kupa akasiyana akakodzera mbeva mamodheru akadai sevanhu uye gene mutation zvinoenderana nezvinodiwa nevatengi, kunyanya gene-edited chirwere mhando dzinogona kunyatso kutevedzera nzira yekukura kwezvirwere zvevanhu, iyo inogona kushandiswa kuongorora uye kuongorora kushanda kwemishonga uye. kuvandudza mwero wekubudirira kwekuvandudzwa kwemishonga mitsva.

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Ropa biochemical index kuongororwa

-In vitro kugogodza-kunze kana kuwandisa kwechinangwa chemajini mune genetically engineered cell lines

-In vivo knock-out kana overexpression yechinangwa chemajini mumamodheru

-In vivo functional assays kusanganisira bundu kukura, metastasis, etc.·

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Kuzvibata kweMhuka

·Kudzidza uye ndangariro kugona bvunzo:

Morris mvura maze (spatial kudzidza ndangariro, kushanda ndangariro, referensi ndangariro, inverted kudzidza, hippocampal-inotsamira ndangariro);Barnes maze (spatial kudzidza uye ndangariro);

· Conditioned Kutya:

Emotional memory, hippocampal-dependent associative conditioned fear, non-hippocampal-dependent cued conditioned fear, kurangarira kwenguva refu, kurangarira kwenguva pfupi, amygdala-dependent memory, uye kutya kupindura.

·Kuzvidya Mwoyo Muedzo:

Yakasimudzwa Cross Maze, Conditioned Kutya Muedzo, Kusavapo Munda Behavior Test, Startle Response, uye Social Interaction Behavior.

·Kuongororwa kwemaitiro ekuora mwoyo:

Novelty environment-induced hypophagia experiment, kurembedza muswe kuyedza, kumanikidzirwa kushambira kuedza, kusaenda kubasa bvunzo, magariro ekudyidzana maitiro, uye kuwana kusaita.

· Miedzo ine chekuita nekurwadziwa:

Kuyera marwadzo nendiro inopisa, kuyerwa kwemarwadzo nemuswe unodedera (infrared heat uye pressure triggered)

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Reference

[1]Othman MZ,Hassan Z, Che Ane AT.Morris maze yemvura: chishandiso chinoshanda uye chakakodzera chekuongorora nzvimbo yekudzidza uye ndangariro.Exp Anim.2022 Aug 5;71(3):264-280.doi:10.1538/expanim.21-0120.Epub 2022 Mar 18. PMID: 35314563;PMCID: PMC9388345.

Taura nesu

LinkedIn:https://www.linkedin.com/company/ motar/
Tel:+86-181 3873 9432
E-mail:MingCelerOversea@mingceler.com

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