Kuongororwa kwechirwere chebundu chekutsvaga
Tumor drug screening, inozivikanwawo sekuti anti-cancer drug screening kana cancer drug testing, zvinoreva nzira yekuongorora mishonga yakasiyana-siyana kuti uone iyo inogona kurapa mabundu nemazvo.Kuongororwa uku kunoitwa kuti kuvheneke nzira dzekurapa dzinogona kuitika kune varwere vegomarara.Inobata basa rakakosha mukugadzirwa kwemishonga mitsva uye kuvandudzwa kwemishonga iripo.
Chinangwa chikuru chekuongororwa kwechirwere chebundu ndechekuona makomisheni anogona kuvharidzira kukura kana kuuraya maseru egomarara uchichengetedza maseru ane hutano.Iyi nzira, inozivikanwa seyakanangwa kurapa, ine chinangwa chekuwedzera kugona kwekurapa uku ichideredza mhedzisiro.Kuongorora kunosanganisira kuisa pasi maseru egomarara, anowanzo kutorwa kubva kumasampuni ebundu kune akasiyana siyana emishonga kuti aone kugona kwavo kushanda mukuuraya maseru egomarara.
Matekinoroji akasiyana-siyana anoshandiswa mukuongorora zvinodhaka zvinodhaka, senge yakakwira-kuburikidza kuongorora, izvo zvinobvumira kukurumidza kuyedzwa kwezviuru zvemakemikari.Iyi nzira inogonesa vaongorori kuti vaone vanovimbisa vavhoti vanogona kuzoongororwazve kushanda kwavo, kuchengetedzeka, uye vangangoitwa kukiriniki.
MingCeler inopa huwandu hwakazara hwemhando yepamusoro preclinical kusimudzira masevhisi ekuongororwa kwemishonga yeoncology uye kusimbiswa, kusanganisira chitupa chekuzivikanwa uye kusimbiswa, in vitro cellular assays uye kuongorora, mu vivo tumor modhi yekuvaka, mu vivo pharmacology, pharmacokinetics, pharmacodynamic uye basic toxicology ongororo.
Zvichienderana nezvinodiwa nevatengi vedu, isu tinokwanisa kupa zvakadzama mechanistic zvidzidzo.
Tumor chinangwa chekuzivikanwa uye kusimbiswa
-In vitro kugogodza-kunze kana kuwandisa kwechinangwa chemajini mune genetically engineered cell lines
-In vivo knock-out kana overexpression yechinangwa chemajini mumamodheru
-In vivo functional assays kusanganisira bundu kukura, metastasis, etc.·
Tumor model
·In situ xenograft
·Intravenous Majekiseni modhi
·muenzanisi wekenza yemapapu metastatic
·Spleen jekiseni chiropa metastasis modhi
·Genetically engineered mbeva modhi
Biochemical uye cellular level yekuyedza
- Pamusoro pe260 STR-yakagadziriswa Humanized bundu cell mitsara iyo inogona kumiririra dzinenge dzese mhando dzebundu
- Cell line uye primary cell test
- Kuongororwa kweMetabolomics
- Compound Screening
- Kusarudzwa kwemasero anonzwira uye anoshivirira
